Why certain anticancer drugs can cause heart failure in some patients

Several types of cancer are characterised by overexpression of PDGFR proteins, and molecules that inhibit PDGFR signalling have proven useful anticancer therapeutics. Recently, however, several such anticancer drugs have been associated with clinical heart failure in some patients. Aarif Khakoo and colleagues, at the University of Texas MD Anderson Cancer Centre, Houston, have now identified a role for PDGFR-beta in mouse heart muscle cells that might help explain why inhibitors of PDGFR signalling can cause heart failure...

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