Influencing craving for cigarettes by stimulating the brain
Targeted brain stimulation increases cigarette cravings, a new study in Biological Psychiatry has found, which may ultimately lead to new treatments that reverse these effects. Cues associated with cigarette smoking, such as watching someone else smoke, elicit craving and may provoke relapse when smokers are attempting to quit. There are many methods that smokers use in an attempt to reduce their craving for cigarettes, including efficacious pharmacologic treatments such as nicotine patches, and alternative approaches such as hypnosis and acupuncture. Scientists have long suspected that these diverse approaches might work through a common mechanism -- the reduction of activity in a brain circuit that is responsible for cigarette craving. This hypothesis is supported by human functional brain imaging studies, which consistently report the activation of several brain regions during craving that involve regions in the cerebral cortex as well as the limbic system, a brain circuit involved in emotion.
Building on these brain imaging studies, scientists at the Center for Nicotine and Smoking Cessation Research at Duke University Medical Center manipulated this 'craving circuit' activity using transcranial magnetic stimulation (TMS), a non-invasive technique that uses electromagnetic currents to target specific or general areas of the brain. Depending upon the frequency used, it can either stimulate or depress brain activity.
The researchers found that the delivery of repeated TMS to the superior frontal gyrus at high frequency (10 Hz) increased craving for cigarettes.
"We directly stimulated a frontal brain region using magnetic fields and showed that it exaggerated smokers' craving for cigarettes when they viewed smoking related cues. By gaining a better understanding of how the brain influences craving responses, strategies for blocking these responses can be devised and ultimately more effective smoking cessation treatments may be developed," explained Dr. Jed Rose, one of the study authors.
However, they did not find that low frequency (1 Hz) stimulation reduced craving. Thus, a potential intervention that may have reduced the activation within this circuit did not produce the opposite effect.
Nonetheless, the high frequency stimulation reduced craving when participants were viewing nonsmoking cues. Moreover, the ability of smoking to satisfy craving, a rewarding effect that helps keep smokers "hooked," was partially blocked by high frequency stimulation. These effects need to be explored for potential therapeutic applications.
"This elegant study implicates the superior frontal gyrus in controlling the activity of the craving circuit," commented Dr. John Krystal, Editor of Biological Psychiatry. "Additional research will be needed to determine the potential value of repetitive TMS as a treatment for smoking."
- Stimulating the brain blunts cigarette cravingWed, 17 Apr 2013, 15:33:47 EDT
- First brain study reveals benefits of exercise on quitting smokingTue, 10 Feb 2009, 10:03:15 EST
- Our brain can be taught to control cravings, Yale researcher findsMon, 2 Aug 2010, 15:24:37 EDT
- UCLA neuroscientists demonstrate crucial advances in 'brain reading'Wed, 21 Dec 2011, 15:36:52 EST
- Smoking mind over smoking matterTue, 13 Jul 2010, 14:36:13 EDT
- Influencing craving for cigarettes by stimulating the brainfrom Science DailyMon, 31 Oct 2011, 14:30:50 EDT
- Influencing craving for cigarettes by stimulating the brainfrom PhysorgMon, 31 Oct 2011, 11:02:03 EDT
- Cigarette smoking's impact lingers after quittingfrom PhysorgMon, 31 Oct 2011, 11:00:54 EDT
- Cigarette Smoking's Impact Lingers after Quittingfrom Newswise - ScinewsMon, 31 Oct 2011, 10:00:42 EDT
- Cigarette smoking’s impact lingers after quittingfrom Science BlogMon, 31 Oct 2011, 10:00:22 EDT
- Scientists hail brain gene findfrom BBC News: Science & NatureMon, 31 Oct 2011, 4:00:34 EDT
- Cigarettes Are Being Used in Studies to Help Smokers Quitfrom NY Times ScienceSat, 29 Oct 2011, 0:40:06 EDT
- Cigarettes Are Being Used in Studies to Help Smokers Quitfrom NY Times HealthFri, 28 Oct 2011, 20:10:16 EDT
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