Tumor suppressor gene TP53 mutated in 90 percent of most common childhood bone tumor
Thursday, April 3, 2014 - 20:31
in Health & Medicine
Mutations in the tumor suppressor gene TP53 have been found in 90 percent of osteosarcomas, suggesting the alteration plays a key role early in development of the bone cancer. The discovery that TP53 is altered in nearly every osteosarcoma also helps to explain a long-standing paradox in osteosarcoma treatment, which is why at standard doses radiation therapy is largely ineffective against the tumor.