Antibiotics as active mutagens in the emergence of multidrug resistance

Multidrug resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA) pose a major problem for patients, doctors, and the pharmaceutical industry. To combat such bacteria, it is critical to understand how resistance is developed in the first place. New research shows that low doses of antibiotics can produce mutant strains that are sensitive to the applied antibiotic but have cross-resistance to other antibiotics.

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