NIST researchers develop a novel approach for the measurement of a crucial DNA repair enzyme in human cells
Wednesday, January 8, 2014 - 10:00
in Biology & Nature
(Phys.org) —NIST researchers recently reported a novel approach for identifying and quantifying an important DNA repair enzyme in mammals including humans. This enzyme, apurinic/apyrimidinic endonuclease 1 (APE1), plays a critical role in base excision repair of DNA damage. APE1 plays a key role in repairing mutagenic base-free sites in DNA by first generating strand breaks which paves the way for other enzymes to fully repair DNA.