Production-Line Hypothesis Ruled Out As Cause Of Miscarriages, Birth Defects

46s years ago, an idea was introduced that the first eggs produced in a female's fetal stage tend to have better connections or "crossovers" between chromosomes and that, as the woman ages and ovulates eggs produced later, her eggs will have more faulty chromosomes, leading to miscarriages and developmental abnormalities.   But after counting the actual chromosome crossovers in thousands of eggs, researchers found those of eggs produced early in the fetal stage were no different from those produced later.  This rules out   the "Production-Line Hypothesis" as one of the leading ideas on why older women have an increased risk of miscarriages and children with birth defects.  read more

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