Scientists reveal how cell corrects errors made in gene transcription
Tuesday, May 3, 2016 - 13:30
in Biology & Nature
The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. Scientists have now built a Markov State Model from extensive molecular dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at atomistic detail. The results reveal that Pol II backtracking occurs in a stepwise mode where two intermediate states are involved.