RNA interference cancer treatment? Delivering RNA with tiny sponge-like spheres

Monday, February 27, 2012 - 11:30 in Biology & Nature

For the past decade, scientists have been pursuing cancer treatments based on RNA interference -- a phenomenon that offers a way to shut off malfunctioning genes with short snippets of RNA. However, one huge challenge remains: finding a way to efficiently deliver the RNA. Scientists have now come up with a novel delivery vehicle in which RNA is packed into microspheres so dense that they withstand degradation until they reach their destinations. The new system knocks down expression of specific genes as effectively as existing delivery methods, but with a much smaller dose of particles.

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