Dual-acting class of antimalarial compounds discovered with potential to prevent and treat malaria

The discovery of a new class of dual-acting antimalarial compounds that target both liver and blood infections, attacking the Plasmodium parasite at both stages in its reproduction cycle, to publish. Scientists developed a novel assay to determine liver stage activity of candidate small molecules, then used the assay and other tools to identify and optimize a chemical scaffold with activity on both blood- and liver-stage parasites in malaria mouse models.

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