HIV integration requires use of a host DNA-repair pathway

The human immunodeficiency virus, the cause of AIDS, makes use of the base excision repair pathway when inserting its DNA into the host-cell genome, according to a new study. The research shows that crippling the repair pathway prevents the virus from completing this critical step in its life cycle. The findings offer potential new targets for novel anti-HIV drugs that may not lead as quickly to viral resistance as current drugs, the researchers say.

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