Experimental treatments for cocaine addiction may prevent relapse

The drug disulfiram, used for years to deter recovering alcoholics from drinking, also can treat cocaine addiction. Disulfiram prevents rats from seeking cocaine after a break, a model for addicts tempted to relapse. Disulfiram appears to work by inhibiting the enzyme dopamine beta-hydroxylase, which is required for the production of the neurotransmitter norepinephrine. A selective inhibitor of that enzyme, nepicastat, is also effective in the same model of cocaine relapse.

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