Inner Workings Of Molecular Thermostat Point To Pathways To Fight Diabetes, Obesity

Researchers have discovered a molecular circuit involving the oxygen-carrying component of hemoglobin -- heme -- that helps maintain proper metabolism in the body, providing new insights into metabolic disorders such as obesity and diabetes. This happens through a molecular pathway that allows the cell to monitor and adjust internal heme levels via Rev-erb±, creating more when heme levels fall, and slowing it down when levels rise.

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