Possible new drug targets for the genetic disorder Noonan syndrome
Tuesday, November 2, 2010 - 10:50
in Health & Medicine
Noonan syndrome is a relatively common genetic disorder characterised by short stature, unique facial features, and heart defects. About 10%-15% of affected individuals have mutations in their SOS1 gene. A team of researchers, led by Raju Kucherlapati, at Harvard Medical School, Boston, has now generated mice expressing a Sos1 mutation associated with Noonan syndrome and used them to identify potential therapeutic targets for the treatment of individuals with Noonan syndrome...