Scientists describe mechanism for rare muscle disease

(Medical Xpress) -- A team of scientists from the Friedrich Miescher Institute for Biomedical Research and the Hebrew University of Jerusalem describe in C. elegans the process leading to a rare form of Emery-Dreifuss muscular dystrophy, a disease caused by a mutation in lamin A in man. Lamin A not only gives shape to the nucleus, but here it is shown that it controls the positioning of genes in the nucleus, thereby guaranteeing proper transcription. In a paper appearing in Current Biology, the authors show that perturbation of tissue-specific gene localization leads to aberrant muscle structure and function.

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