How yeast chromosomes avoid the bad breaks
Sunday, August 7, 2011 - 12:30
in Biology & Nature
The human genome is peppered with repeated DNA elements that can vary from a few to thousands of consecutive copies of the same sequence. During meiosisthe cell division that produces sperm and eggsrepetitive elements place the genome at risk for dangerous rearrangements from genome reshuffling. This recombination typically does not occur in repetitive DNA, in part because much of it is assembled into specialized heterochromatin. Other mechanisms that restrain recombination in repetitive DNA have remained elusive, until now.