Genome-scale study of 100 cell lines pinpoints vulnerabilities in ovarian cancer

Cancer is not invincible but its weaknesses can be difficult to detect. An effort known as Project Achilles — named after the Greek warrior whose one vulnerability led to his undoing — was launched to develop a systematic way of pinpointing these weak spots. In their largest and most comprehensive effort to date, researchers from the Broad Institute of MIT and Harvard and the Dana-Farber Cancer Institute examined cells from over 100 tumors, including 25 ovarian cancer tumors, to unearth the genes upon which cancers depend. One of these genes, PAX8, is altered in a significant fraction of ovarian tumors — nearly one-fifth of those surveyed in the study. Their results appear online July 11 in Proceedings of the National Academy of Sciences.

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