Faster CARS, less damage: Chemical microscopy shows potential for cell diagnostics

A paper by researchers at the National Institute of Standards and Technology may breathe new life into the use of a powerful -- but tricky -- diagnostic technique for cell biology. The paper,* appearing this week in the Biophysical Journal, demonstrates that with improved hardware and better signal processing, a powerful form of molecular vibration spectroscopy can quickly deliver detailed molecular maps of the contents of cells without damaging them. Earlier studies have suggested that to be useful, the technique would need power levels too high for cells.

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