Scientists discover how a tumor suppressor induces senescence and staves off cancer
Tuesday, April 13, 2010 - 10:43
in Health & Medicine
A frequently mutated gene in human cancers is the reitnoblastoma (RB) gene, which controls a potent tumor suppression pathway. Mutations in the gene disable the vast and intricate RB pathway in virtually all tumor cells, leading to disturbances in a host of cellular functions and ultimately provoking cancer. But which of these functions is crucial for the gene's tumor-suppressing activity has been uncertain.