New Look Identifies Crucial Clumping of Diabetes-Causing Proteins

Subtle differences in the shape of proteins protect some and endanger others. "All mammals make this same protein called amylin, and it only differs a little bit from species to species," says Martin Zanni, a University of Wisconsin-Madison chemistry professor. "The mammals that get type 2 diabetes, their amylin proteins aggregate in the pancreas into plaque that kills the cells around them. As a result, you can't make insulin."

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