How cells tolerate DNA damage -- start signal for cell survival program identified
Monday, November 16, 2009 - 17:42
in Biology & Nature
Cancer researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have gained new insights into how cells react to DNA damage. Dr. Michael Stilmann, Dr. Michael Hinz and Professor Claus Scheidereit have shown that the protein PARP-1, which detects DNA damage within seconds, activates the transcription factor NF-kappaB, a well-known regulator of gene expression. NF-kappaB triggers a survival program, which blocks programmed cell death. The activation of NF-kappaB is thought to be one of the potential causes for tumor cell resistance to chemo and radiation therapy. (Molecular Cell, online, doi 10.1016/j.molcel.2009.09.032; Preview: doi 10.1016/j.molcel.2009.10.022)*.