Heavy exercise may produce asthma-like symptoms even in healthy children
Children who undergo brief periods of intense exercise may exhibit lung dysfunction or other symptoms similar to those experienced by asthma patients, even when no history of asthma exists, according to a study conducted by researchers at the University of California's Irvine and Miller Children's Hospital. The results of the study will be presented at the ATS 2010 International Conference in New Orleans.
"Studies have shown that in adults, vigorous exercise can cause wheezing and a decrease in pulmonary function testing (PFT), even when there is no prior history of asthma," said lead author and hospital clinician Alladdin Abosaida, M.D. "However, the extent of exercise-associated PFT abnormality in healthy children has received relatively less attention.
"The results of this study indicate that short bouts of heavy exercise do cause a decrease in lung function testing in healthy children without a history of asthma or allergies," he said
Dr. Abosaida and colleagues examined the effects of exercise in 56 healthy children with no clinical history of asthma or allergy, measuring lung function following each exercise test.
"We evaluated two exercise protocols in each child – a constant work rate exercise test commonly used for evaluation of exercise-induced asthma, and a progressive exercise test typically used to determine an individual's aerobic capacity," Dr. Abosaida said.
Nearly half of the children tested had at least one abnormal result when pulmonary function was measured following exercise, he noted. Decrements in PFT measurements typically occurred when bronchial tubes – the primary airways allowing air to enter and exit the lungs – become constricted in response to rigorous activity. This effect, called bronchoconstriction, can arise as the result of an inflammatory response triggered by heavy exercise.
Dr. Abosaida said the results were surprising.
"We did not expect to see pulmonary function abnormalities after short periods of heavy exercise in such a large number of healthy children in our subject population," he said. "We speculate that either the inflammatory response to exercise or cellular changes that may occur as the result of dehydration of the airway surface, or both, led to mild airway obstruction."
Additional research will need to be focused on determining the mechanism of lung dysfunction in children following heavy exercise, and may help identify potential interventions, Dr. Abosaida said.
"More studies are needed to understand the pathogenesis and management plan of exercise-induced bronchoconstriction in healthy children," he added. "In addition, further comparisons are needed between the two exercise protocols for screening of bronchoconstriction to avoid the false negative results that may occur by using a single type of test."
Source: American Thoracic Society
Articles on the same topic
- Children with severe asthma at increased risk of developing COPDSun, 16 May 2010, 15:43:16 EDT
- Heavy exercise may produce asthma-like symptoms even in healthy childrenfrom Science CentricWed, 19 May 2010, 8:30:56 EDT
- Heavy exercise may produce asthma-like symptoms even in healthy children, study findsfrom Science DailyTue, 18 May 2010, 18:30:44 EDT
- Heavy exercise may produce asthma-like symptoms even in healthy childrenfrom PhysorgTue, 18 May 2010, 17:30:51 EDT
- Study demonstrates art therapy's effectiveness in pediatric asthmafrom Science DailySun, 16 May 2010, 23:21:13 EDT
- Children with severe asthma at increased risk of developing COPD, study findsfrom Science DailySun, 16 May 2010, 20:31:07 EDT
- Children with severe asthma at increased risk of developing COPDfrom PhysorgSun, 16 May 2010, 18:00:30 EDT
- Children with severe asthma at increased risk of developing COPDfrom Science CentricSun, 16 May 2010, 17:01:09 EDT
- Children with severe asthma at increased risk of developing COPDfrom Science BlogSun, 16 May 2010, 15:40:39 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Stanford team achieves 'holy grail' of battery design: A stable lithium anode
- Common blood thinner for pregnant women proven ineffective: Lancet study
- New research suggests Saharan dust is key to the formation of Bahamas' Great Bank
- Four billion-year-old chemistry in cells today
- Hubble finds 3 surprisingly dry exoplanets
- Smithsonian scientist and collaborators revise timeline of human origins
- Meet the gomphothere: UA archaeologist involved in discovery of bones of elephant ancestor
- New view of Rainier's volcanic plumbing
- Domestication syndrome: White patches, baby faces and tameness
- Extinct human cousin gave Tibetans advantage at high elevation