Anti-inflammatory drugs may defeat a treatment-resistant type of cancer
Effective drugs for treating a chemotherapy-resistant form of lymphoma might already be on the market according to a study that has pieced together a chemical pathway involved in the disease. By following the trail of several molecular flags that mark this type of cancer, a team from the University of California, San Diego, the Burnham Institute for Medical Research and the University of Copenhagen Hospital have discovered that anti-inflammatory drugs used to treat arthritis will shrink lymphoma tumors in mice.
Their report, published in the July issue of the journal EMBO Molecular Medicine, also strengthens evidence for a link between inflammation and cancer.
"If this shows promise with early clinical experiments, the treatment would be immediately available," said Michael David, a professor of biology who leads the group at UC San Diego.
The research focused on a type of non-Hodgkin lymphoma called diffuse large B-cell lymphoma. In some patients with the disease, chemotherapy works well. In a recent study of 40 patients more than 75 percent of patients with one form of this type of lymphoma survived five years or longer.
But that study also identified a group of patients whose cancer proved difficult to treat. Their tumors failed to respond to chemotherapy, and only 16 percent of patients with this form of lymphoma survived more than five years after they were diagnosed.
Several molecular flags mark this treatment-resistant lymphoma, but the links between them were unknown until now. The new paper reports that tumor cells isolated from these patients have depressed levels of a protein called SHIP1, which was known to suppress tumors. In fact, patients with the lowest levels of SHIP1 are the least likely to survive.
The resistant type of lymphoma cells also have elevated levels of miR-155, a specific example of a type of genetic material called microRNA, the team found. They demonstrated that miR-155 suppresses SHIP1 by sticking to the template for the protein, preventing its manufacture.
This raised the possibility that these patients might respond favorably to a treatment that interrupted that pathway. "It makes sense to block that loop," said Irene Pedersen, a research scientist in the Division of Biological Sciences at UC San Diego and lead author of the paper.
The final clue came from earlier reports that an inflammatory molecule called TNFα could boost levels of miR-155. Additional laboratory work confirmed the observation for this type of lymphoma cell.
"Our study strengthens the scientific link between inflammation and tumor progression," David said. "The prevailing thought is that you need two mutations to get cancer. But it might take just one mutation plus inflammation."
The anti-inflammatory drugs etanercept and infliximab, which are currently used to treat arthritis and inflammatory bowel disease, work by suppressing TNFα, suggesting a new way to curb the malignancy of this type of lymphoma.
The team tested the idea in mice that had been injected with aggressive lymphoma cells and found that nascent tumors shrank in six days.
"It's a promising result of this whole translational path," said Pedersen, whose initial training was in cancers of the blood. "To get somewhere we had to study the mouse models and the molecular profiles. I hope it will be beneficial to patients."
Patients with lymphoma that has not responded to chemotherapy and who are ineligible for a bone-marrow transplant will be the first to receive the new treatment. The team in Copenhagen has begun recruiting patients for an initial clinical study.
- Anti-inflammatory drugs may defeat a treatment-resistant type of cancerfrom Science CentricThu, 25 Jun 2009, 6:21:19 EDT
- Anti-inflammatory drugs may defeat a treatment-resistant type of cancerfrom PhysorgWed, 24 Jun 2009, 22:21:03 EDT
- Anti-inflammatory Drugs May Defeat Treatment-resistant Type Of Cancerfrom Science DailyWed, 24 Jun 2009, 18:28:10 EDT
- Anti-inflammatory drugs may defeat a treatment-resistant type of cancerfrom Science BlogWed, 24 Jun 2009, 16:35:14 EDT
Latest Science NewsletterGet the latest and most popular science news articles of the week in your Inbox! It's free!
Learn more about
Check out our next project, Biology.Net
From other science news sites
Popular science news articles
- Astronomers discover powerful aurora beyond solar system
- Researchers design first artificial ribosome
- World's first bilateral hand transplant on child at Children's Hospital of Philadelphia
- Dense star clusters shown to be binary black hole factories
- Chimpanzees binge on clay to detox and boost the minerals in their diet
- Astronomers discover Earth's bigger cousin
- Rice disease-resistance discovery closes the loop for scientific integrity
- Study finds abrupt climate change may have rocked the cradle of civilization
- Bossy cock takes the lead vocal of cock-a-doodle-do
- Scripps researchers map out trajectory of April 2015 earthquake in Nepal
- Rosetta spacecraft sees sinkholes on comet
- Seahorse tails could inspire new generation of robots
- Newly discovered 48-million-year-old lizard walked on water in Wyoming
- Human brain study by UCLA and UK researchers sheds light on how new memories are formed
- Live imaging reveals how wound healing influences cancer