Genome-wide map shows precisely where microRNAs do their work

MicroRNAs are the newest kid on the genetic block. By regulating the unzipping of genetic information, these tiny molecules have set the scientific world alight with their therapeutic potential and wide-ranging applications. But the question remains: How do they work? By using a technique that molecularly cements proteins to RNAs, Rockefeller scientists have decoded a map of microRNA-messenger RNA interactions in the mouse brain, an advance that holds promise for biology and human disease.

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