Feedback from thousands of designs could transform protein engineering
Friday, July 14, 2017 - 18:02
in Physics & Chemistry
A large-scale study to test the actual stability of computationally designed proteins shows a way to take some of the guesswork out of protein engineering. Previously, scientists tested only a few tens of proteins, due to prohibitive costs of DNA. This new approach, which incorporates advances in DNA synthesis technology, efficiently checks thousands of mini-protein designs. The hope is that in the future a similar approach could test bigger, more complex, designed proteins.