Organ transplant rejection may not be permanent
Tuesday, July 7, 2015 - 14:00
in Health & Medicine
Rejection of transplanted organs in hosts that were previously tolerant may not be permanent, report scientists. Using a mouse model of cardiac transplantation, they found that immune tolerance can spontaneously recover after an infection-triggered rejection event, and that hosts can accept subsequent transplants as soon as a week after. This process depends on regulatory T-cells, a component of the immune system that acts as a 'brake' for other immune cells.