Estrogen increases cannabis sensitivity, study shows

Smoking today's concentrated pot might be risky business for women, according to new research. Thanks to their estrogen levels, female rats are at least 30 percent more sensitive than males to the pain-relieving qualities of THC -- the key active ingredient in cannabis, research shows. Females also develop tolerance to THC more quickly. These sensitivities could increase vulnerability to negative side effects like anxiety, paranoia and addiction.

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