New technology detects cellular memory, aids in understanding of how diseases such as cancer arise
In 2009, a new technology was developed that could elucidate the mystery behind cellular memory. Building on this technology, researchers have now identified 100 new molecular players that ensure cellular knowledge of own identity at cell division. This is crucial for fetal development, to maintain body functions throughout life and prevent disease. Understanding the fundamental principles of how chromatin is faithfully duplicated is essential to understand how our organism is developed and maintained, and also how diseases such as cancer arise. If cells lose their chromatin memory, they can potentially develop into cancer cells and form tumors. Such a loss of what is also called 'epigenetic' memory is now known to be involved in almost all cancer types.