Epigenetic cause of osteoarthritis identified

In breakthrough research, scientists discovered that osteoarthritis sufferers have a signature epigenetic change responsible for switching on and off a gene that produces a destructive enzyme. MMP13 contributes to the destruction of joint cartilage, making it and the epigenetic changes causing its increased levels, targets for drug development. This research also shows how epigenetic changes play a role in diseases outside of cancer.

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