Computer-designed proteins programmed to disarm variety of flu viruses

Proteins found in nature, but that do not normally bind the flu, can be engineered to act as broad-spectrum antiviral agents against many flu virus strains, including H1N1 pandemic influenza. One engineered protein has a flu-fighting potency that rivals several monoclonal antibodies. The proteins are constructed via computer modeling to fit neatly onto a nano-sized target on flu viruses, and prevent that part of the virus from changing shape to infect cells.

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