Genetically influenced responses to alcohol affect brain activation both with and without alcohol

A low level of response (LR) to alcohol reflects at least in part a low brain response to alcohol and carries significant risk for the later development of alcoholism. A new study used functional magnetic resonance imaging to examine brain activation in individuals with low and high LRs to alcohol while they performed a cognitive task. Significant differences detected in brain activation may contribute to the inability by individuals with a low LR to recognize modest levels of alcohol intoxication.

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