New drug aids gout patients not helped by standard treatments

Injections of pegloticase can produce significant and sustained clinical improvements in many patients with chronic gout that is resistant to conventional therapies. In two clinical trials, pegloticase rapidly lowered high levels of uric acid, the biochemical abnormality in gout. Forty percent of patients had complete resolution of at least one of the painful swollen joint nodules that are a hallmark of severe gout.

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