Genetic basis for muscle endurance discovered in animal study

Researchers have identified a gene for endurance, or more precisely, its negative regulator. Not having the gene relates to greater endurance in the knockout mice that were studied. The investigators also showed that the gene is linked to Olympic-level athletes in endurance sports such as swimming compared to athletes in sprint sports such as the 100-meter dash. The work has implications for improving muscle performance in disease states including metabolic disorders, obesity, and aging.

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