Kinetochores prefer the 'silent' DNA sections of the chromosome

Tuesday, July 5, 2011 - 12:31 in Biology & Nature

The protein complex responsible for the distribution of chromosomes during cell division is assembled in the transition regions between heterochromatin and euchromatin. The centromere is a specialized region of the chromosome, on which a protein complex known as the kinetochore is assembled. During cell division, the kinetochore provides a point of attachment for molecules of the cytoskeleton, thereby mediating the segregation of chromosomes to the two opposing cell poles. Scientists have investigated the factors that play an essential role in the development of the kinetochore. According to new findings, both the organization of the chromosomes and epigenetic marks determine the location where a kinetochore and, eventually, a centromere can form.

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