Two-sided immune cell could be harnessed to shrink tumors
Thursday, October 28, 2010 - 12:30
in Biology & Nature
Researchers have found that a protein called inducible costimulator (ICOS) is necessary for the growth and function of human Th17 cells, while CD28, a transmembrane protein on CD4 cells, stops the ICOS signal. What's more, human Th17 stimulated with ICOS shrank human tumors implanted in a mouse model faster than those stimulated with CD28.