... one that activates the programmed cell death pathway--reduces the number of tumor metastases in mouse models of kidney and breast cancer. The combination also prolonged overall survival in mice with ...
Researchers have developed a new mouse model of Costello syndrome (CS) -- an inherited disorder that affects many parts of the body, causing multiple symptoms; for example, effects on the brain and ...
... reduced both endogenous and drug-induced resistance to chemotherapy in a mouse model of melanoma. The NF-ºB pathway is often active in human cancers and promotes resistance to cytotoxic ...
... pronounced improvement in neuropathology and cognitive function in mouse models of Alzheimer's Disease (AD). Recent ... permeability, in two well established Tg mouse models of AD. The Tg mice examined ...
... of the journal Neuron, reveals new details about the pathogenesis of postpartum depression and provides a mouse model that may lead to development of new treatments for mood disorders associated with ...
Lapatinib reduces the number of large brain metastases in a mouse model of metastatic breast cancer, relative to untreated mice, researchers report.
... for at least a year.
Earlier this year, in experiments involving a different type of mouse model for progeria, a group of researchers from Spain and France reported that a combination of statin and ...
... to target breast cancer, in which the BRCA1-gene plays a role, in a genetically engineered mouse model. Treatment resulted in tumor regression and a strong increase in survival without signs of ...
... to target breast cancer, in which the BRCA1-gene plays a role, in a genetically engineered mouse model. Treatment resulted in tumor regression and a strong increase in survival without signs of ...
... support the inhibition of DOT1L as a potential therapeutic approach in this disease and that this mouse model should be useful for assessment of therapeutic approaches for MLL-rearranged ALL," offers ...
... , such as abnormal movement, balance, and coordination.
Not only does this work present a new mouse model to study demyleinating disease, but it also stresses the importance of PAD in maintaining ...
... developed a new transgenic mouse model of CJD expressing the mouse homolog of the D178N/V129 ... CJD. "Our results establish the first animal model of a genetic prion disease recapitulating cognitive, ...
Researchers at the Salk Institute for Biological Studies have developed a versatile mouse model of glioblastoma—the most common and deadly brain cancer in humans—that closely resembles the development ...
Chicago researchers report the development of a new mouse model for food allergy that mimics symptoms generated ... S. Fauci, M.D. "Finding an animal model that mimics a severe human allergic reaction to ...
... Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases worked with a mouse model for SLE and demonstrated that IL21 signaling is essential for the SLE-like autoimmune ...
