Elucidating side effects of antineoplastic agent

Cisplatin, an anticancer drug widely used for treating various types of tumor, can induce side effects in the short term. A team of scientists has provided first in vitro evidence that this antitumor agent modifies the sensitivity of cellular pressure sensors. This completely novel mechanism could help to elucidate certain neurological side effects of cisplatin hitherto unexplained. These results could open potential avenues for improving the chemotherapeutic efficacy of cisplatin-based compounds. The researchers now plan to test them on animal models.

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