Mice engrafted with human immune cells may provide clues to better prevention and treatment of typhoid fever

Better treatments and prevention of typhoid fever may emerge from a laboratory model that has just been developed for the disease. The model is based on transplanting human immune stem cells from umbilical cord blood into mice that are susceptible to infections. Because typhoid fever affects only humans, progress in creating effective vaccines and medications has been limited. The "humanized" mouse allows scientists to study innovative approaches against human infections.

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