What Happens When Immune Cells Just Won't Die?

X-linked lymphoproliferative disease (XLP) is a rare inherited immunodeficiency most commonly caused by deficiency in the protein SAP. New research now provides an explanation as to how SAP deficiency causes boys with XLP to develop an extreme, usually fatal, accumulation of activated immune cells known as cytotoxic T lymphocytes following infection with the common virus that causes mono.

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