New Mouse Model Of Severe Kidney Disease Leads To Potential New Therapy
Wednesday, September 2, 2009 - 22:07
in Health & Medicine
X-linked nephrogenic diabetes insipidus (XNDI) is a severe congenital kidney disease for which there is no specific, effective drug treatment, mainly because there are no good animal models of the disease. Researchers have now developed a viable mouse model of XNDI. Disease was associated with increased kidney expression of the protein EP4. Selective EP4 receptor agonists alleviated all the symptoms of disease and could be of benefit to individuals with XNDI.