Potential Risk Identified In Transfusions Of Platelets Before Bone Marrow Transplant

A larger number of platelet transfusions given before a bone marrow transplant to treat bone marrow failure syndromes correlates with a greater risk of transplant rejection. A model system in mice shows that platelet transfusions can increase the risk of later bone marrow transplant rejection, even when donor and recipient are MHC "matched." More research is necessary to determine if the same mechanisms occur in humans. Modification of transfused platelets or matching for "minor antigens" on donated platelets may be potential remedies.

Read the whole article on Science Daily

More from Science Daily