Cancer-inhibiting Compound Found Under The Sea

Saturday, August 9, 2008 - 22:28 in Biology & Nature

Researchers have discovered a marine compound off the coast of Key Largo that inhibits cancer cell growth in laboratory tests. Largazole, named for its Florida location and structural features, seeks out a family of enzymes called histone deacetylase. Overactivity of certain HDACs has been associated with several cancers such as prostate and colon tumors, and inhibiting HDACs may activate tumor-suppressor genes that have been silenced in these cancers.

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