B Cells Can Act Alone In Autoimmune Disease

B cells, the source of damaging autoantibodies, have long been thought to depend upon T cells for their activation and were not considered important in the initiation of autoimmune diseases like lupus or rheumatoid arthritis. An article in the journal Immunity turns this paradigm on its head by showing that in systemic autoimmune diseases B cells can be activated the absence of T cells.

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