Novel Targeted Therapy Reduces Chemoresistance In Mouse Model Of Melanoma
Wednesday, June 11, 2008 - 07:21
in Biology & Nature
A novel small molecule inhibitor reduced both endogenous and drug-induced resistance to chemotherapy in a mouse model of melanoma. The NF-ºB pathway is often active in human cancers and promotes resistance to cytotoxic chemotherapy drugs. Some cytostatic drugs, such as doxorubicin, induce NF-ºB pathway activity.