Defining what it means to be a naive stem cell

Whitehead Institute scientists have created a checklist that defines the "naive" state of cultured human embryonic stem cells (ESCs). Such cells can mature into almost any cell type and more closely resemble the unique molecular features of pluripotent cells in the early human embryo than conventional ESCs in later stages of development. Although scientists have been very interested in working with naive stem cells, they have lacked a common definition of what makes a cell truly naive.

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