A bulky catalyst induces pinpoint targeting on benzene to create bioactive molecules
Tuesday, April 14, 2015 - 08:30
in Physics & Chemistry
Tuning the para position of benzene moieties is significant for creating biologically active compounds and optoelectronic materials. Yet, attaching a functional handle specifically at the para position of benzene has been challenging due to multiple reactive sites on the ring. Chemists at ITbM, Nagoya University have developed a novel iridium catalyst that enables highly para-selective borylation on benzene, leading to the rapid synthesis of drug derivatives for treating Parkinson's disease.