Tiny biomolecular tweezers studying force effect of cells
A new type of biomolecular tweezers could help researchers study how mechanical forces affect the biochemical activity of cells and proteins. The devices—too small to see without a microscope—use opposing magnetic and electrophoretic forces to precisely stretch the cells and molecules, holding them in position so that the activity of receptors and other biochemical activity can be studied. Arrays of the tweezers could be combined to study multiple molecules and cells simultaneously, providing a high throughput capability for assessing the effects of mechanical forces on a broad scale. Details of the devices, which were developed by researchers at the Georgia Institute of Technology and Emory University in Atlanta, were published February 19, 2014, in the journal Technology.