From embryonic stem cells, a sperm replacement and easier path to genetic modification

Researchers reporting in the April 27 issue of the journal Cell have devised a new and improved method for producing genetically modified animals for use in scientific research. The method relies on haploid embryonic stem cells (haESCs) instead of sperm to artificially fertilize immature egg cells. Such stem cells are similar to sperm in that they carry only genetic material from a mouse "dad."

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