Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells
Friday, February 10, 2012 - 09:01
in Biology & Nature
A research group including Kyoto University researchers demonstrates that mouse iPS cells, in which genetic correction occurs spontaneously through mitotic recombination, is selectable from the population of genetically mutated iPS cells in the mouse model of autosomal dominant polycystic kidney disease (ADPKD). This technology could be applicable of genome editing in human iPS cells for curing patients with genetic disorders.