Scientists identify key enzyme in microbial immune system

Thursday, September 9, 2010 - 15:07 in Biology & Nature

Imagine a war in which you are vastly outnumbered by an enemy that is utterly relentless - attacking you is all it does. The intro to another Terminator movie? No, just another day for microbes such as bacteria and archaea, which face a never-ending onslaught from viruses and invading strands of nucleic acid known as plasmids. To survive this onslaught, microbes deploy a variety of defense mechanisms, including an adaptive-type nucleic acid-based immune system that revolves around a genetic element known as CRISPR, which stands for Clustered Regularly Interspaced Short Palindromic Repeats.

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