A new indicator of poor prognosis in node-negative colorectal cancer patients

Tumor buds are single cells or clusters of up to five cells at the invasive tumor front of colorectal tumors which are important for patient outcome and hypothesized to have stem-cell like properties. A research group in Switzerland has investigated the expression of putative cancer stem cell markers in tumor buds of patients with colorectal cancer identifying expression of ABCG5 as a frequent event associated with poor prognosis.

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